Healthcare facilities that provide urgent care and emergency services are first points of contact for returning travelers who might have Ebola. This module provides guidance to emergency departments for developing plans and procedures for screening all patients for relevant travel history, risk factors for Ebola, and signs and symptoms that might be consistent with Ebola. Important concepts are outlined regarding safe, patient- and family-centered screening procedures that can appropriately diagnose and manage Ebola or other illnesses while ensuring respect for the patient and protection of the patient’s privacy throughout the screening process.